Getting Started with Your 23andMe Reports

If you have just received your 23andMe® reports, you may be wondering where to start. After all, there is a lot about you that makes you unique. In this article you will find a brief introduction to the reports provided by 23andMe and other key information to help you get started exploring your genetics.

If you are new to the world of genetics or it has been a while since your last genetics class, you can review a few concepts about genetics in our Tutorials.

This article will discuss the following topics:

• Accessing your account
• How to set your profile information (applicable to Health + Ancestry Service profiles only)
• How to print a summary of your reports
• The 23andMe report categories and the information each category provides
• The limitations of the reports (applicable to Health + Ancestry Service profiles only)

See list of navigational links.

Reminder: If you purchased the Ancestry Service, you will not see reports on Carrier Status*, Health Predisposition*, or Wellness in your account.

Accessing Your Account

After you receive an email announcing “Your reports are ready”, you will need to log in to your online 23andMe account using the email address you provided during the registration process—this is the same email address used to announce that your data was ready.

Your 23andMe reports and our interactive features are only accessible from within your account.

• If you forgot the password connected to your account, you can reset it here.
• If you forgot or lost access to the email address connected to your account, please contact us.

Take me to the Sign In page.

Setting Your Profile Information

This section is applicable to the Health + Ancestry Service and the 23andMe+ Membership.

Ethnicity

After you have successfully logged into your account, you are asked to supply your ethnicity. Our Carrier Status* Reports explain your results in the context of your ethnicity. Some associations between genotype and phenotype are better studied in certain populations and are most applicable to people of a particular ethnic background. If a genetic condition has been studied in your ethnicity, our reports may provide more detailed information for you. As new scientific studies are published, we’ll continue working to expand our tests to include variants applicable to more ethnicities.

You can review or edit your ethnicity information at any time from within your account. Keep in mind that your Carrier Status reports will not be available to you until you have completed this information.

We do not use your self-reported ethnicity information to compute your Ancestry Composition.

Take me to the page where I can review or edit my ethnicity information.

Reports Configuration

You will be asked to choose whether you would like to include or exclude all Carrier Status Reports*, Health Predisposition Reports* (including Genetic Health Risk) , and Pharmacogenetics Reports**. Some of our health reports provide information about genetic risks for health conditions that could be relevant for you, your future children, and potentially other family members. Our Pharmacogenetics reports can provide information on how your DNA may impact the way your body processes certain medications.

Deciding whether or not you want to learn about these risks is a personal choice. You have control over what types of information you would like to see and can choose to exclude certain reports that you may not want to view. You may also wish to review important information about our Genetic Health Risk* and Carrier Status* Reports. Keep in mind that Pharmacogenetics Reports** are available to 23andMe+ members exclusively.

If you choose to exclude these categories of reports, you can choose to include them at a later time from within your account settings. You will also have the choice to remove these reports from view at a later time, however, please remember that once you have viewed your genetic information, the knowledge is irrevocable.

It is important to note that reports on Wellness and Traits are always visible for profiles that purchased the Health + Ancestry Service.

Take me to the page where I can choose whether to receive health reports.

Reports Requiring Additional Opt-in

The Late-Onset Alzheimer’s Disease Genetic Health Risk Report*, Parkinson’s Disease Genetic Health Risk Report*, BRCA1/BRCA2 (Selected Variants) Genetic Health Risk Report*, MUTYH-Associated Polyposis (MAP) Genetic Health Risk Report*, and, for 23andMe+ members, Hereditary Prostate Cancer (HOXB13-Related) Genetic Health Risk Report* require you to make an additional choice after you have agreed to receive health reports. Some of these reports are about serious diseases that may not currently have an effective treatment or cure. Others may have effective treatment or prevention options, but these actions may carry their own health risks. We understand that some people may choose not to learn about these types of personal risks or risks for their family members. For additional information about each health condition and report, click the "Learn more" link next to the title of the report on the reports configuration page.

If you choose to exclude these reports, you will have the option to include them at a later time from within your account settings. You are welcome to opt-in to some, all, or none of these reports.

Printing a Summary of Your Reports

The 23andMe reports are only accessible from within your account; you must log in to your account to print your reports. To print an individual report, click on the Print button in the upper-right corner of the report.

To print a summary of your reports, simply login and select either Health or Ancestry Section from the top navigation menu. Next, click on All Reports from the dropdown menu, then click on the Report Summary button in the upper-right corner.

Take me to a printable summary of my reports.

Introducing the different categories of 23andMe Reports

You can explore what your DNA says about you in the 23andMe Reports—accessible by selecting the categories available to you from the top navigation bar or the side panel of your homepage. The categories of reports available to you depend on the service purchased—Ancestry Service, Health + Ancestry Service, Health Service, or Health + Ancestry Service with 23andMe+ Membership. Learn more about our DNA test kit service options.

23andMe offers six categories of reports—Ancestry, Carrier Status*, Health Predispositions*, Pharmacogenetics**, Wellness, and Traits.

Understanding the Limitations of Your Reports on Health and Traits

Is 23andMe Diagnostic?

No, 23andMe reports do not diagnose any health conditions or provide medical advice. The 23andMe Carrier Status Reports* can tell you if you have specific genetic variants that you could pass on to your future children, from saliva collected using an FDA-cleared collection device (Oragene DX model OGD.500.001). Carrier Status tests are not intended to diagnose a disease, or tell you anything about your risk for developing a disease in the future. However, for certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Each Carrier Status Report is most relevant for people of certain ethnicities. On their own, these tests are not intended to tell you anything about the health of your fetus, or your newborn child’s risk of developing a particular disease later in life.

The 23andMe Health Predisposition Reports* help you learn how your genetics can influence your chances of developing certain health conditions. This category includes FDA authorized Genetic Health Risk* Reports. The 23andMe Genetic Health Risk Reports tell you if you have genetic variants that are associated with an increased risk of developing certain health conditions but do not report on your (a user’s) entire genetic profile. While having a particular variant can be linked to a higher risk for a condition, it does not necessarily mean you will develop the condition. It is important to remember that these reports do not cover all possible genetic variants that could influence risk for these conditions and that other non-genetic factors, such as environment and lifestyle, can also influence risk for these conditions. Consult with a healthcare professional if the condition runs in your family, you think you might have the condition, or you have questions about any genetic or nongenetic risk factors you may have.

The 23andMe+ Pharmacogenetics** Reports tell you about DNA variants that may influence your body’s ability to process some medications. The 23andMe+ Pharmacogenetics reports cover three genes: CYP2C19, DPYD, and SLCO1B1 and also include three Medication Insight reports on citalopram, and clopidogrel, and simvastatin. It is important to remember that these reports do not include all possible DNA variants that may affect how your body processes medications and that other factors -- such as lifestyle or other health factors -- may also affect your ability to process medications.

Do not use these reports to start, stop, or change any course of treatment. Medications should always be taken as directed. If you have questions or concerns about the medication you are taking, please discuss these with your healthcare provider. Keep in mind that these reports are available exclusively to 23andMe+ members.

The 23andMe Wellness Reports make connections between your DNA that may relate to healthy living, however, other genetic and nongenetic factors may affect whether or not you display a specific trait. Consult with a healthcare professional before making any major lifestyle changes.

The 23andMe Traits Reports make connections between your DNA and your features and characteristics. It is important to keep in mind that although these reports predict your genetic chances of having a trait, many other factors can influence your actual traits.

Receiving "Variant not determined" or "Result not determined"

In some cases, we are not able to provide a result for a particular report. If results cannot be provided for a report, you will see “Variant not determined” or “Result not determined”. If you are seeing this result, our algorithm may not have been able to confidently determine your genotype. All genetic markers used in our reports are evaluated for high data quality and accuracy. Occasionally, a person's data may not allow us to determine his or her genotype confidently at a particular marker. In regard to your Carrier Status reports, in certain instances a "not determined" result may appear if a person has two copies of a variant. In most cases, our Carrier Status reports can only determine if someone is a carrier (has only one copy) of the tested variants. Most reports cannot determine if an individual has two copies of the same variant.

Some “not determined” variants are expected in the raw data and not a cause for concern.

It is important to keep in mind that our tests do not diagnose any health conditions.

Additional Resources

• 23andMe Sign In
• DNA Basics (tutorial)
• Printable summary
• Ancestry Composition Report
• Maternal Haplogroup Report
• Paternal Haplogroup Report
• Neanderthal Ancestry Report
• Carrier Status Reports
• Health Predisposition Reports
• Wellness Reports
• Traits Reports
• Locate and connect with relatives using the DNA Relatives feature
• Share your reports with family members or friends
• Access your uninterpreted, raw genetic data
• Conditions not included in the 23andMe reports
• Sample status information
• Important test information

*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet FDA requirements for genetic health risks and reports which are based on 23andMe research and have not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child's risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of 44 variants in the BRCA1 and BRCA2 genes. The report describes if a person's genetic result is associated with an increased risk of developing breast cancer and ovarian cancer and may be associated with an increased risk for prostate cancer, pancreatic cancer, and potentially other cancers. The variants included in this report do not represent the majority of the BRCA1/BRCA2 variants in people of most ethnicities. The MUTYH-Associated Polyposis Genetic Health Risk Report is indicated for reporting the Y179C and G396D variants in the MUTYH gene and an increased risk for colorectal cancer. The two variants included in this report are most common in people of Northern European descent. The Hereditary Prostate Cancer (HOXB13-Related) Genetic Health Risk report is indicated for reporting the G84E variant in the HOXB13 gene. The report describes if a person has the G84E variant and if a male is at increased risk for prostate cancer. The variant included in this report is most common in people of European descent, especially in people of Northern European descent. These reports do not include variants in other genes linked to hereditary cancers and the absence of variants included in this report does not rule out the presence of other genetic variants that may impact cancer risk. These reports are for over-the-counter use by adults, and provide genetic information to inform discussions with a healthcare professional. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. For important information and limitations regarding other genetic health risk reports and carrier status reports, visit 23andme.com/test-info/

**23andMe PGS Pharmacogenetics reports: The 23andMe test uses qualitative genotyping to detect 3 variants in the CYP2C19 gene, 2 variants in the DPYD gene and 1 variant in the SLCO1B1 gene in the genomic DNA of adults from saliva for the purpose of reporting and interpreting information about the processing of certain therapeutics to inform discussions with a healthcare professional. It does not describe if a person will or will not respond to a particular therapeutic. Our CYP2C19 Pharmacogenetics report provides certain information about variants associated with metabolism of some therapeutics and provides interpretive drug information regarding the potential effect of citalopram and clopidogrel therapy. Our SLCO1B1 Pharmacogenetics report provides certain information about variants associated with the processing of some therapeutics and provides interpretive drug information regarding the potential effect of simvastatin therapy. Our DPYD Pharmacogenetics report does not describe the association between detected variants and any specific therapeutic. Results for DPYD and certain CYP2C19 results should be confirmed by an independent genetic test prescribed by your own healthcare provider before taking any medical action. Warning: Test information should not be used to start, stop, or change any course of treatment and does not test for all possible variants that may affect metabolism or protein function. The PGS test is not a substitute for visits to a healthcare professional. Making changes to your current regimen can lead to harmful side effects or reduced intended benefits of your medication, therefore consult with your healthcare professional before taking any medical action. For important information and limitations regarding Pharmacogenetic reports, visit 23andme.com/test-info/pharmacogenetics/