The Colorectal Cancer PRS Report is intended to provide an estimate of the likelihood of developing this common type of cancer, based on your genetics. Genetic results are available for individuals who are determined to have predominantly European or Hispanic/Latino ancestry. However, genetic results are not available for individuals who are determined to have other genetic ancestries. These include people whose genetic ancestry is predominantly:
- Sub-Saharan African/African American
- East/Southeast Asian
- South Asian
- Northern African/Central & Western Asian
To explain, this report is based on a statistical model developed by 23andMe that estimates the likelihood of developing colorectal cancer. This model takes into account your genetic variants at many genetic markers, along with your genetic ancestry and the birth sex you reported in your account settings. To calculate this estimate, we used data from 23andMe customers who have consented to participate in research.
However, we do not have enough data from 23andMe research participants of certain ancestries to create a genetic prediction for them that meets our scientific standards at this time. This means genetic results are not available for these groups.
While personalized genetic results may not be available to you for this report, we encourage you to review the general information regarding prevention, family history, and more on the Colorectal Cancer Condition Page [https://you.23andme.io/health/condition/colorectal_cancer/]. This information is available to all customers. Regardless of ancestry, everyone has a chance of developing colorectal cancer and can benefit from taking steps like getting screened when your doctor recommends it, eating less red meat, and getting regular physical activity.
We are always striving to improve our data collection and scientific methods, and hope to improve our ability to create genetic predictions that meet our scientific standards for all customers in the future. As part of these efforts, 23andMe launched the Genetic Insights into Colorectal Cancer in the Black Community study, which we hope will help to improve the performance of genetic models for colorectal cancer in the future. If you would like more information about this research, you can learn more here.
As new research is conducted, we hope that we'll be able to provide more tailored information to all of our customers.
*Please note that this report is based on 23andMe Research and has not been reviewed by the FDA. The report also does not describe a person’s overall likelihood of developing Colorectal Cancer, does not account for lifestyle or family history and is not intended to tell you anything about your current state of health, or to be used to make medical decisions or determine any treatment.