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23andMe Chip Platforms

The 23andMe Personal Genetic Service® analyzes the DNA in your sample using microarray genotyping. 23andMe periodically updates its genotyping chip in order to take advantage of improvements in technology, to make updates to information provided in the Personal Genetic Service, or to offer flexibility for future research.

The genotyping chip your sample was tested on impacts which genetic markers are included in your raw data, and in some cases, the reports available in your account. The most notable difference between genotyping chips are the health-related reports available to you in your online account, access to the most recent population updates in the Ancestry Composition feature, and a more seamless sharing experience with individuals on our V5 chip.

This article will address the following topics:

 

Tip: You can view which chip version was used to process your sample from within your account. The genotyping chip version is listed in the Personal Information section of your Account Settings.

 

Key Information About 23andMe Chip Upgrades
  • Currently, Chip Upgrades are only available to customers where the original order was shipped to the United States and were genotyped on V1, V2, V3, and V4 platforms.
  • The 23andMe kit that you receive as part of the Chip Upgrade purchase must only be used by the person for whom the kit was intended.
  • You will need to provide a new sample into the collection kit, and this kit will be automatically registered to the profile for which the upgrade order was placed.
  • New results will be applied to your existing 23andMe profile.
  • Chip Upgrades are non-refundable.

 

Health-related Reports Offered to Each Chip Version

Health-related reports offered after a chip upgrade for customers genotyped on V1 or V2

Customers who were genotyped on version 1 and version 2 chips have the option to upgrade to the current chip version and receive all available reports in the Health Predisposition Reports* and Carrier Status* categories.

New Reports Available to V1 and V2 Customers with a Chip Upgrade

All available reports in the Health Predisposition category

All available reports in the Carrier Status category

Deep Sleep Wellness Report

Bunions Traits Report

Flat Feet Traits Report

Fear of Public Speaking Trait Reports

 

Health-related reports offered after a chip upgrade for customers genotyped on V3 or V4A

Customers who were genotyped on version 3 or version 4 have the option to upgrade to the current chip and receive reports certain reports only available to customers on the current genotyping chip.

New Reports Available to V3 and V4A with a Chip Upgrade

Type 2 Diabetes Health Predisposition Report (Powered by 23andMe Research)

Familial Hypercholesterolemia Genetic Health Risk Report*

Hereditary Amyloidosis TTR-Related Genetic Health Risk Report*

MUTYH-Associated Polyposis Genetic Health Risk Report*

Familial Mediterranean Fever Carrier Status Report*

Bunions Traits Report

Flat Feet Traits Report

Fear of Public Speaking Traits Report

 

23andMe Health Reports by Chip Version

    • Health Predisposition Reports
    • Carrier Status Reports
    • Wellness Reports
    • Traits Reports
    • See All
Health Predisposition Reports*
Report Name V1 V2 V3 V4A V4 V5
MUTYH-Associated Polyposis
Type 2 Diabetes (Powered by 23andMe Research)
Familial Hypercholesterolemia
Hereditary Amyloidosis TTR-Related
Age-Related Macular Degeneration
Alpha-1 Antitrypsin Deficiency
BRCA1/BRCA2 (Selected Variants)
Celiac Disease
G6PD Deficiency
Hereditary Hemochromatosis (HFE-Related)
Hereditary Thrombophilia
Late-Onset Alzheimer’s Disease
Parkinson’s Disease
Carrier Status Reports*
Report Name V1 V2 V3 V4A V4 V5
Familial Mediterranean Fever
Agenesis of the Corpus Callosum with Peripheral Neuropathy
ARSACS
Autosomal Recessive Polycystic Kidney Disease
Beta Thalassemia and Related Hemoglobinopathies
Bloom Syndrome
Canavan Disease
Congenital Disorder of Glycosylation Type 1a (PMM2-CDG)
Cystic Fibrosis
D-Bifunctional Protein Deficiency
Dihydrolipoamide Dehydrogenase Deficiency
Familial Dysautonomia
Familial Hyperinsulinism (ABCC8-Related)
Fanconi Anemia Group C
Gaucher Disease Type 1
Glycogen Storage Disease Type Ia
Glycogen Storage Disease Type Ib
GRACILE Syndrome
Hereditary Fructose Intolerance
Herlitz Junctional Epidermolysis Bullosa (LAMB3-Related)
Leigh Syndrome, French Canadian Type
Limb-Girdle Muscular Dystrophy Type 2D
Limb-Girdle Muscular Dystrophy Type 2E
Limb-Girdle Muscular Dystrophy Type 2I
Maple Syrup Urine Disease Type 1B
MCAD Deficiency
Mucolipidosis Type IV
Neuronal Ceroid Lipofuscinosis (CLN5-Related)
Neuronal Ceroid Lipofuscinosis (PPT1-Related)
Niemann-Pick Disease Type A
Nijmegen Breakage Syndrome
Nonsyndromic Hearing Loss and Deafness, DFNB1 (GJB2-Related)
Pendred Syndrome and DFNB4 Hearing Loss
Phenylketonuria and Related Disorders
Primary Hyperoxaluria Type 2
Rhizomelic Chondrodysplasia Punctata Type 1
Salla Disease
Sickle Cell Anemia
Sjögren-Larsson Syndrome
Tay-Sachs Disease
Tyrosinemia Type I
Usher Syndrome Type 1F
Usher Syndrome Type 3A
Zellweger Syndrome Spectrum (PEX1-Related)
Wellness Reports
Report Name V1 V2 V3 V4A V4 V5
Deep Sleep
Alcohol Flush Reaction
Caffeine Consumption
Genetic Weight
Lactose Intolerance
Muscle Composition
Saturated Fat and Weight
Sleep Movement
Traits Reports
Report Name V1 V2 V3 V4A V4 V5
Bunions
Flat Feet
Fear of Public Speaking  ✗  ✗  ✗  ✓  ✓
Ability to Match Musical Pitch
Asparagus Odor Detection
Cheek Dimples
Cleft Chin
Dandruff
Earlobe Type
Earwax Type
Eye Color
Fear of Heights
Finger Length Ratio
Freckles
Hair Photobleaching
Hair Texture
Hair Thickness
Light or Dark Hair
Misophonia
Mosquito Bite Frequency
Motion Sickness
Newborn Hair
Photic Sneeze Reflex
Red Hair
Skin Pigmentation
Stretch Marks
Toe Length Ratio
Unibrow
Widow's Peak
Health Predisposition Reports*
Report Name V1 V2 V3 V4A V4 V5
MUTYH-Associated Polyposis
Type 2 Diabetes (Powered by 23andMe Research)
Familial Hypercholesterolemia
Hereditary Amyloidosis TTR-Related
Age-Related Macular Degeneration
Alpha-1 Antitrypsin Deficiency
BRCA1/BRCA2 (Selected Variants)
Celiac Disease
G6PD Deficiency
Hereditary Hemochromatosis (HFE-Related)
Hereditary Thrombophilia
Late-Onset Alzheimer’s Disease
Parkinson’s Disease

 

Carrier Status Reports*
Report Name V1 V2 V3 V4A V4 V5
Familial Mediterranean Fever
Agenesis of the Corpus Callosum with Peripheral Neuropathy
ARSACS
Autosomal Recessive Polycystic Kidney Disease
Beta Thalassemia and Related Hemoglobinopathies
Bloom Syndrome
Canavan Disease
Congenital Disorder of Glycosylation Type 1a (PMM2-CDG)
Cystic Fibrosis
D-Bifunctional Protein Deficiency
Dihydrolipoamide Dehydrogenase Deficiency
Familial Dysautonomia
Familial Hyperinsulinism (ABCC8-Related)
Fanconi Anemia Group C
Gaucher Disease Type 1
Glycogen Storage Disease Type Ia
Glycogen Storage Disease Type Ib
GRACILE Syndrome
Hereditary Fructose Intolerance
Herlitz Junctional Epidermolysis Bullosa (LAMB3-Related)
Leigh Syndrome, French Canadian Type
Limb-Girdle Muscular Dystrophy Type 2D
Limb-Girdle Muscular Dystrophy Type 2E
Limb-Girdle Muscular Dystrophy Type 2I
Maple Syrup Urine Disease Type 1B
MCAD Deficiency
Mucolipidosis Type IV
Neuronal Ceroid Lipofuscinosis (CLN5-Related)
Neuronal Ceroid Lipofuscinosis (PPT1-Related)
Niemann-Pick Disease Type A
Nijmegen Breakage Syndrome
Nonsyndromic Hearing Loss and Deafness, DFNB1 (GJB2-Related)
Pendred Syndrome and DFNB4 Hearing Loss
Phenylketonuria and Related Disorders
Primary Hyperoxaluria Type 2
Rhizomelic Chondrodysplasia Punctata Type 1
Salla Disease
Sickle Cell Anemia
Sjögren-Larsson Syndrome
Tay-Sachs Disease
Tyrosinemia Type I
Usher Syndrome Type 1F
Usher Syndrome Type 3A
Zellweger Syndrome Spectrum (PEX1-Related)

 

Wellness Reports
Report Name V1 V2 V3 V4A V4 V5
Deep Sleep
Alcohol Flush Reaction
Caffeine Consumption
Genetic Weight
Lactose Intolerance
Muscle Composition
Saturated Fat and Weight
Sleep Movement

 

Traits Reports
Report Name V1 V2 V3 V4A V4 V5
Bunions
Flat Feet
Fear of Public Speaking  ✗  ✗  ✗  ✓  ✓
Ability to Match Musical Pitch
Asparagus Odor Detection
Cheek Dimples
Cleft Chin
Dandruff
Earlobe Type
Earwax Type
Eye Color
Fear of Heights
Finger Length Ratio
Freckles
Hair Photobleaching
Hair Texture
Hair Thickness
Light or Dark Hair
Misophonia
Mosquito Bite Frequency
Motion Sickness
Newborn Hair
Photic Sneeze Reflex
Red Hair
Skin Pigmentation
Stretch Marks
Toe Length Ratio
Unibrow
Widow's Peak

 

Common Questions

How do I purchase a chip upgrade?

You can purchase a chip upgrade by visiting: https://you.23andme.com/chip-upgrade/

 

Who is eligible for an upgrade?

Most customers genotyped on a previous version of the 23andMe platform are eligible to purchase a chip upgrade. At this time, we are genotyping customers on the V5 chip. Therefore customers genotyped on V1-V4 and shipped their original kit to the United States are eligible to purchase a chip upgrade. Customers in Canada, United Kingdom, Denmark, Finland, Ireland, Sweden, or The Netherlands will have chip upgrades made available to them in the coming months.

 

Are upgrades available to customers in all countries?

At this time, customers in the United States are eligible for chip upgrades. Customers in Canada, United Kingdom, Denmark, Finland, Ireland, Sweden, or The Netherlands will have chip upgrades made available to them in the coming months.

 

If I moved outside of the country where my kit was originally shipped, what should I do?

If you no longer reside in the same country that your kit was originally shipped to, you are not eligible to purchase a chip upgrade. The product offering available in each country is dependent on the regulatory environment in that region. For this reason, we cannot send a new kit to a different country. You will need to purchase a new kit, and create a new profile if you’d like the most up-to-date product experience available in your current place of residence.

 

Why can’t my stored sample be used?

The option to use a stored sample to upgrade to the newest platform is not available at this time. By providing a new kit, we are ensuring the most effective retest experience for our customers.

 

Do I have to upgrade?

No, 23andMe will not take away any reports that are currently available to each customer. However, choosing not to upgrade means that you may not receive newly released reports. You may be eligible to upgrade to the latest chip in the future if you do not upgrade now.

 

What happens to my raw data?

Raw data generated from both analyses will be combined in the Browse Raw Data file. Please note, you will be unable to filter which positions were processed using the V3 chip and which were processed on the v5 chip. Learn more about Raw Data.

 

What happens to my sharing connections?

The new kit for your upgrade will be automatically registered to your existing profile. As such, your connections will not be erased or affected. Please be aware that with the exception of sensitive health reports, (BRCA1/BRCA2 (Selected Variants), Late-Onset Alzheimer’s Disease, Parkinson’s Disease, and MUTYH-associated Polyposis) any new reports, as well as updated results will automatically be shared to your existing connections once you’ve been upgraded.

 

 

 

*The 23andMe PGS test includes health predisposition and carrier status reports. Health predisposition reports include both reports that meet US FDA requirements for genetic health risks and the 23andMe Type 2 Diabetes health predisposition report which is based on 23andMe research and has not been reviewed by the FDA. The test uses qualitative genotyping to detect select clinically relevant variants in the genomic DNA of adults from saliva for the purpose of reporting and interpreting genetic health risks and reporting carrier status. It is not intended to diagnose any disease. Your ethnicity may affect the relevance of each report and how your genetic health risk results are interpreted. Each genetic health risk report describes if a person has variants associated with a higher risk of developing a disease, but does not describe a person’s overall risk of developing the disease. The test is not intended to tell you anything about your current state of health, or to be used to make medical decisions, including whether or not you should take a medication, how much of a medication you should take, or determine any treatment. Our carrier status reports can be used to determine carrier status, but cannot determine if you have two copies of any genetic variant. These carrier reports are not intended to tell you anything about your risk for developing a disease in the future, the health of your fetus, or your newborn child's risk of developing a particular disease later in life. For certain conditions, we provide a single report that includes information on both carrier status and genetic health risk. Warnings & Limitations: The 23andMe PGS Genetic Health Risk Report for BRCA1/BRCA2 (Selected Variants) is indicated for reporting of the 185delAG and 5382insC variants in the BRCA1 gene and the 6174delT variant in the BRCA2 gene. The report describes if a woman is at increased risk of developing breast and ovarian cancer, and if a man is at increased risk of developing breast cancer or may be at increased risk of developing prostate cancer. The three variants included in this report are most common in people of Ashkenazi Jewish descent and do not represent the majority of BRCA1/BRCA2 variants in the general population. The MUTYH-Associated Polyposis Genetic Health Risk Report is indicated for reporting the Y179C and G396D variants in the MUTYH gene and an increased risk for colorectal cancer. The two variants included in this report are most common in people of Northern European descent. These reports do not include variants in other genes linked to hereditary cancers and the absence of variants included in these reports do not rule out the presence of other genetic variants that may impact cancer risk. The PGS test is not a substitute for visits to a healthcare professional for recommended screenings or appropriate follow-up. Results should be confirmed in a clinical setting before taking any medical action. For important information and limitations regarding other genetic health risk reports and carrier status reports, visit https://www.23andme.com/test-info.


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