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What does "not determined" or "not genotyped" mean?

The raw data provided by 23andMe is an advanced view of all the uninterpreted raw genotype data, including data that is not used in 23andMe reports. This data has undergone a general quality review however only a subset of markers have been individually validated for accuracy. As such, the data from 23andMe's Browse Raw Data feature is suitable only for research, educational, and informational use and not for medical or other use.

In some cases, a user will not have data at a SNP location. There are two possibilities: variant not determined or variant not genotyped.

Not determined: In order to ensure that the data we return to customers is highly accurate, we use a stringent algorithm to make genotype calls. Occasionally, a user's data may not allow us to confidently determine his or her genotype at a particular marker. When the algorithm cannot make a confident genotype call, it gives a "no call" result instead.

It is possible that future review will allow us to call the genotype, but until that time, the data does not appear. In downloaded data, the entry for any uncalled SNPs displays '--' instead of a two-letter genotype.

Not genotyped: 23andMe periodically updates its DNA analysis platform to take advantage of improvements in technology. The platform used in the analysis of your sample dictates which SNPs we are able to provide data for. While many SNPs included in the raw data are available for all customers, customers tested on different platforms will have some different variants available in the raw data. If a particular SNP was not included on the platform you were genotyped on, your results for this variant will appear as "not genotyped" in the raw data feature.


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